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Stenting versus Endarterectomy for Treatment of Carotid ...
The Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) investigators and committee members are listed in the Appendix. Robert W. Hobson, II, M.D., is deceased. Article
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The CREST trial: Stenting versus endarterectomy for ...
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is one of the largest randomized controlled trials comparing these two treatment modalities. Prior to publication of these results, several trials had found higher rates of stroke and death associated with carotid artery stenting leading to a trend towards endarterectomy.
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Carotid Revascularization Endarterectomy Versus Stenting ...
The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA (transient ischemic attack ...
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A Summary of the CREST Trial - Endovascular Today
The Carotid Revascularization Endarterectomy Versus Stent Trial (CREST) was designed in the late 1990s and was started in 2000. 1,2 At the time, there had been no adequate, randomized comparisons of carotid endarterectomy (CEA) and protected carotid artery stenting (CAS). Endarterectomy had been well established to be superior to medical therapy in stroke prevention in the symptomatic but ...
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CREST - Wiki Journal Club
The Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) compared stenting to endarterectomy in the management of symptomatic and asymptomatic carotid artery stenosis. Prior studies demonstrated stenting as a valid alternative to CEA but yielded conflicting results, and a large-scale comparison study had not yet been done.
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Carotid Revascularization Endarterectomy vs. Stenting ...
The results of the CREST trial indicate that CAS is associated with similar rates of periprocedural stroke, death, MI, and subsequent ipsilateral strokes up to 10 years, as compared with CEA in a contemporary population. This was true for both genders, and irrespective of the presence or absence of symptoms.
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CREST-2: Medical study to prevent stroke caused by plaque ...
The two procedures available in this trial are carotid endarterectomy (en-dar-ter-EK-ta-mee) and carotid stenting. All study participants will receive intensive medical management to help control their risk factors for stroke. W hy C REST-2? CREST-2 physicians want to find the best way to prevent strokes. Over the past 20 ...
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Design of the Carotid Revascularization Endarterectomy vs ...
The Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) is a prospective, randomized, parallel, two-arm, multi-center trial with blinded endpoint adjudication. Primary endpoints are analyzed using standard time-to-event statistical modeling with adjustment for major baseline covariates. Primary analysis is on an intent-to-treat ...
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Effect of Carotid Revascularization Endarterectomy Versus ...
Background: CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) results, published in 2010, showed no difference in the rates of composite outcome (stroke, myocardial infarction, or death) between carotid artery stent placement (CAS) and carotid endarterectomy (CEA). Objective: To identify any changes in use and outcomes of CAS and CEA subsequent to the CREST results.
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