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CREST-2: Medical study to prevent stroke caused by plaque ...
CREST-2 is intended to compare the two procedures to intensive medical management with drugs and lifestyle modification in patients without recent stroke and without stroke warning signs. The information from this study will help us learn the best way to prevent strokes in other people like you.
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Carotid Revascularization and Medical Management for ...
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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CREST-2 Randomized Control Trial - The Vascular Quality ...
The CREST-2 Trial goals are to compare medically managed patients versus Carotid Endarterectomy and to compare medically managed patients versus carotid artery stent procedure. CREST-2 will enroll a maximum of 2,480 participants at 120 medical centers across the United States and Canada. The physicians are chosen to participate in CREST-2 based ...
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CREST-2 trial. How is it designed and what for?
CREST-2 Trial: Asymtomatic >70% carotid stenosis Trial 1 : 1240 patients Intensive Medical Management (IMM) IMM + CEA Trial 2 : 1240 patients Intensive Medical Mangement (IMM) IMM + CAS Decision of allocation to Trial 1 or 2 : according to the treating team
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The CREST Trial - ACPGBI
CReST – Reasons patients did not have surgery Stent (N=24) Indication changed from potentially curative to palliative post stenting 12 Palliative at randomisation 8 Died post stenting prior to elective surgery (D=3, D=7) 2 Patient declined surgery 2 Surgery (N=3) Non-cancer patient 1 Crossover to stent + palliative chemo post stent (PI ...
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The new england journal medicine
CREST is a randomized, controlled trial with blind - ed end-point adjudication. Ethics review boards at all participating centers approved the protocol.
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The CREST trial: Stenting versus ... - 2 Minute Medicine
The CREST trial found no significant difference in a composite outcome of stroke, myocardial infarction, and death between the two treatment groups (hazard ratio 1.11; 95%CI 0.81-1.51) and achieved lower rates of complications in both groups than those observed in previous trials. This supported both procedures as safe and effective treatment ...
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CREST - Wiki Journal Club
CREST demonstrated that stenting and CEA were similar in regards to the primary outcome of periprocedural stroke, MI, death, or ipsilateral stroke within 4 years. Secondary analyses revealed more periprocedural strokes with stenting (4.1% vs. 2.3%) but fewer periprocedural MIs (1.1% vs. 2.3%).
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Stenting versus Endarterectomy for Treatment of Carotid ...
The rates of ipsilateral stroke during our follow-up period — 2.0% with carotid-artery stenting and 2.4% with carotid endarterectomy — are similar to the rates in the SPACE trial and EVA-3S ...
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